Université de Montréal - Kinésiologie - Laboratoire recherche Jean-Marc Lavoie
 
 

EXERCISE AND LIVER METABOLISM RESEARCH LABORATORY

Director: Jean-Marc Lavoie, Ph.D.


The metabolic research laboratory on liver and exercise is situated on the 6th floor of sports complex (CEPSUM) at the Université de Montréal. The research program of this laboratory is directed towards the study of the afferent contribution of the liver to the metabolic and hormonal responses during different situations such as exercise, fasting, diabetes, and obesity. Specifically, the nature of the stimulus at the origin of the afferent contribution of the liver and the pathway through which the information is conveyed are studied. Most of these studies are conducted on rats in which experimental models are developes using surgical and blood sampling approaches. Recently, this laboratory has started to use hepatic in situ perfusion approach. Technical support is provided by a full-time biochemist and research collaborations with the departments of Nutrition (Dr. G. van de Werve) and Pharmacology (Dr. M. Gascon-Barré), the Faculty of Pharmacy (Dr. N. Yamaguchi) and the liver research laboratory of Dr. P.-M.Huet of St-Luc hospital. Actually, there are 4 Ph.D., and 1 M.Sc. students and 1 visiting professor from Japan working in this laboratory. Anglophone students may submit their thesis or dissertation in English and, although lectures are in French, required reading is generally in English. Professors in the Department are bilingual, and accept assignments in English.

Current major foci:

Role of the liver on the autoregulation of insulin secretion

Studies of hepatic osmoreceptors and metabolic regulation during exercise

Studies on the role of liver ATP levels on metabolic regulation during exercise.

Effects of physical training on ovariectomy-induced obesity

Effects of exercise on hepatic zonation

Recent publications (* graduate students):

Tadjoré, M.*, R. Bergeron*, M. Latour*, F. Désy*, C. Warren*, and J.-M. Lavoie. Effects of dietary manipulations and glucose infusion on glucagon response during exercise in rats. J. Appl. Physiol. (in Press), 1997.

Trabelsi, F.* and J.-M. Lavoie. Arginine-induced pancreatic hormone secretion during exercise in rats. J. Appl. Physiol. 81: 2528-2533, 1996.

Trabelsi, F.*, M. Tadjoré*, M. Latour*, R. Hélie, and J.-M. Lavoie. Nutritional status influences the insulin response produced by acute hepatic vagotomy. Physiol. Behav. 60: 855-860, 1996.

Lavoie, J.-M. and S. Cardin. Role of hepatic nerves on metabolic and hormonal responses to exercise. in: Liver Innervation (ed: T.Shimazu): 145-150, 1996.

Tadjoré, M.*, F. Trabelsi*, R. Hélie, R. Bergeron*, and J.-M. Lavoie. Effet d'une médullosurrénalectomie sur la réponse hormonale induite par une vagotomie hépatique aiguë. Archives of Physiology and Biochemistry. 104: 2-7, 1996.

Trabelsi, F.*, R. Hélie, and J.-M. Lavoie. Effect of hepatic vagotomy on plasma insulin levels during fasting in rats. Physiol. Behav. 58: 1111-1115, 1995.

Latour, M.G.*, S. Cardin, R. Hélie, N. Yamaguchi, and J.-M. Lavoie. Effect of hepatic vagotomy on plasma catecholamines during exercise-induced hypoglycemia. J. Appl. Physiol. 78: 1629-1634, 1995.

Trabelsi, F.*, R. Hélie, R. Bergeon*, and J.-M. Lavoie. Effect of inhibition of gluconeogenesis on arginine-induced insulin secretion. Physiol. Behav. 57: 797-802, 1995.

Trabelsi, F.*, R. Hélie, R. Bergeon*, and J.-M. Lavoie. Effect of inhibition of gluconeogenesis on arginine-induced insulin secretion. Physiol. Behav. 57: 797-802, 1995.

(Français)

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